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Full Text While the beneficial versus detrimental implications of the senescence-associated secretome remain an issue of debate, time-resolved analyses of its composition, regulatory mechanisms and functional consequences have been largely missing.

The dynamic activity of NOTCH is now shown to direct two distinct senescence phenotypes, by first promoting a pro-senescent TGF-β1-dependent secretome, followed by a second wave of pro-inflammatory, senescence-clearing cytokines.

First, the CHA‐VASc score for thromboembolic risk stratification incorporates female sex as an independent risk factor for thromboembolic events.13 Its incorporation into current AF guidelines may have increased provider awareness of higher thromboembolic risk in women and thus increased OAC use.14, 15 Second, the development of non–vitamin K oral anticoagulants (NOAC) has expanded treatment options for patients with AF.

Extracellular vesicles, such as exosomes, are important effectors in the formation of tumour-fostering niches.

Pigmented melanosomes are now shown to have a relevant role in establishing a tumour niche in primary melanoma by reprogramming dermal fibroblasts into cancer-associated fibroblasts through the transfer of mi R-211.

But even as smoking rates have fallen, oral cancer rates have remained about the same, and researchers have documented in recent studies that this may be caused by HPV.

HPV infects cells of the skin and the membranes that lines areas such as the mouth, throat, tongue, tonsils, rectum and sexual organs.


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